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Parkinson's disease (shaking palsy) is a slowly progressive disease of the brain, which is characterised by shaking and difficulty with co-ordination, walking and movement, and was first described in England by James Parkinson in 1817.

The disease is associated with damage to the part of the brain that controls muscle movement, and it is usually slowly progressive, affecting one or both sides of the body. It may involve speech difficulties, an overall mental deterioration, dementia and changes to emotional responses. Some people with Parkinson's disease also become severely depressed - although early loss of mental capacities is uncommon.

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