emotional diseaseThe scans unearthed that in a lot of people with borderline personality disorder, three regions of the brain were either reduced than expected or had atypical degrees of activity. These parts were: 1. the amygdala: which plays an important role in controlling feelings, in particular the more "negative" emotions, for example horror, aggression and worry, 2. the hippocampus: which allows control conduct and self-manage, 3. the orbitofrontal cortex: which is involved in preparing and evaluation making. troubles with these regions of the brain may well contribute to indications of borderline personality disorder. The development of these parts of the brain is influenced by your early childhood. These parts of your brain are also accountable for emotional state regulation, which may explain some of the problems people with borderline personality disorder have in close interactions. Environmental elements of the borderline personality disorder: a number of environmental factors seem to be well-known and widespread among people with borderline personality disorder. These comprise: 1. being a victim of emotional, physical or sex-related mistreatment, 2.